|Pharmaceutical Secondary Standard; Certified Reference Material
Glutathione, Certified Reference Material (Sigma-Aldrich)
CAS number: 70-18-8
Chemical Formula: H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
Molar Mass: 307.32g/mol
Synonyms: γ-L-Glutamyl-L-cysteinyl-glycine, L-Glutathione reduced, GSH
Amino Acid Sequence
Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms. GSH is also a key determinant of redox signalling and protection against oxidative stress.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Gas Chromatography (GC): suitable
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
|30 × 50 cm
3 – 5 weeks