Phorbol 12-myristate 13-acetate, ≥99% (TLC, Sigma-Aldrich)

Description

CAS number: 16561-29-8
Chemical Formula: C36H56O8
Molar Mass: 616.83g/mol
Synonyms: 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA

General description

Phorbol 12-myristate 13-acetate is a phorbol ester. It works as a tumour promoter and is involved in gene transcription, cell growth, differentiation, programmed cell death, immune pathway and receptor desensitization via protein kinase C (PKC) signalling pathways. Phorbol 12-myristate 13-acetate is also a model agent to study growth factors-, hormones-, and cytokines-mediated regulation of cellular growth and differentiation.

Application

Phorbol 12-myristate 13-acetate has been used for the stimulation of various cells including spleen cells, quiescent lymphocytes and fetal thymocytes. It has also been used for the activation of PKC (protein kinase C) in cells.

Solubility

DMSO: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions. DMSO solutions can be stored dark at -20 °C for at least six months.)

Ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.)